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      Piperoxan (hydrochloride)研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-27                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Piperoxan-hydrochloride.htmlPiperoxan (hydrochloride)/a產(chǎn)品描述：Piperoxan hydroch
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Piperoxan-hydrochloride.html">Piperoxan   (hydrochloride)</a>產(chǎn)品描述：Piperoxan hydrochloride is an   α<sub>2</sub> adrenoceptor antagonist.
      
            
      
            IC50 & Target: adrenoceptor<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> When the medulla is   superfused with α<sub>2</sub> adrenoceptor antagonist Piperoxane   (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF),   the three inactive preparations display rhythmic phrenic bursts at a low   frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones   significantly increases during the last 3 min of Piperoxane applications   (163±12% of the previous mean frequency). In active medullary preparations,   the effects of NA applications (25 μM; 5 min) are compared when the   preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor   antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone   (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the   phrenic burst frequency. However, the blockage of the medullary α2   adrenoceptors by Piperoxane potentiates a phr<br><br>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/piperoxan-hydrochloride.html">www.medchemexpress.cn/piperoxan-hydrochloride.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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